Intestinal uptake and biodistribution of novel polymeric micelles after oral administration.
(2006) Journal of Controlled Release — Vol. 111, n° 1-2, p. 47-55 (2006)
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- Abstract
- To determine the fate of polymeric micelles after oral administration, we investigated the possible transport of polymeric micelles across Caco-2 monolayers and their biodistribution in rats after per os administration of [14C]-labelled mmePEG750P(CL-co-TMC) micelles containing risperidone (BCS Class II drug). mmePEG750P(CL-co-TMC) was able to cross Caco-2 monolayer via a saturable transport mechanism. The oral bioavailability of the polymer was 40%. Polymeric micelles based on mmePEG750P(CL-co-TMC) showed very low clearance by the reticuloendothelial system (RES) and a renal excretion. A sustained release of risperidone was observed.
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Mathot, F., van Beijsterveldt, L., Préat, V., Brewster, M., & Ariën, A. (2006). Intestinal uptake and biodistribution of novel polymeric micelles after oral administration. Journal of Controlled Release, 111(1-2), 47-55. https://doi.org/10.1016/j.jconrel.2005.11.012 (Original work published 2006)