The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of [(18)F]-fluoro-deoxy-glucose

Neveu, Marie-Aline;Bol, Vanesa;Bol, Anne;Bouzin, Caroline;Gallez, Bernard;et.al.
(2015) Radiotherapy & Oncology — Vol. 116, n° 3, p. 400-403 (2015)

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Abstract
We investigated the impact of oxygenation status (measured by EPR oximetry) on the uptake of (18)F-FDG (measured by PET) in two different tumor models during a carbogen breathing challenge. We observed a significant drop in (18)F-FDG uptake under carbogen breathing that suggests a rapid metabolic adaptation to the oxygen environment.
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Neveu, M.-A., Bol, V., Bol, A., Bouzin, C., Grégoire, V., Feron, O., Jordan, B., & Gallez, B. (2015). The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of [(18)F]-fluoro-deoxy-glucose. Radiotherapy & Oncology, 116(3), 400-403. https://doi.org/10.1016/j.radonc.2015.04.023 (Original work published 2015)