Vocal Fold Augmentation with Calcium Hydroxylapatite: Twelve-Month Report
(2009) The Laryngoscope — Vol. 119, n° 5, p. 1033-1041 (2009)
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- Objectives: To evaluate the long-term effectiveness of calcium hydroxylapatite (CaHA) vocal fold injection for patients with glottal insufficiency. Study Design: Multicenter, open-label, prospective clinical study of CaHA vocal fold injection. Methods: Each patient served as his/her own control. Voice-related outcome measures were collected for pre-injection, 1, 3, 6, and 12 months. Results: Sixty-three patients were available for evaluation. Fifty-three percent of the injection procedures were done in the office. Fifty-seven percent of patients were diagnosed with unilateral paralysis and 43% with glottal incompetence with mobile vocal folds. Patient satisfaction 12 months after injection showed 67% reporting a significant improvement in voice and 81% reporting at least a moderate improvement in voice. Utilizing the Voice Handicap Index-10, visual analog scale (vocal effort), Consensus Assessment Perceptual Evaluation V (judgments of voice severity), and objective voice measures of glottal closure (maximum phonation time and S:Z ratio), paired t tests showed significant improvements after treatment. A 22% further treatment rate was found at the 12-month time point. Conclusions: One-year results in this large cohort of patients with glottal incompetence treated with CaHA vocal fold injection demonstrate that excellent clinical results were achieved.
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Rosen, C. A., Gartner-Schmidt, J., Casiano, R., Anderson, T. D., Johnson, F., Remacle, M., Sataloff, R. T., Abitbol, J., Shaw, G., Archer, S., & Zraick, R. I. (2009). Vocal Fold Augmentation with Calcium Hydroxylapatite: Twelve-Month Report. The Laryngoscope, 119(5), 1033-1041. https://doi.org/10.1002/lary.20126 (Original work published 2009)