Influence of the thymus on transplantation tolerance in miniature swine.

Yamada, K;Gianello, Pierre;Ierino, F L;Shimizu, A;Sachs, D H;et.al.
(1997) Transplantation Proceedings — Vol. 29, n° 1-2, p. 1076 (1997)

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Authors
  • Yamada, K
    Author
  • Gianello, PierreUCLouvain
    Author
  • Ierino, F L
    Author
  • Shimizu, A
    Author
  • Sachs, D H
    Author
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Abstract
TOLERANCE to kidney allografts in miniature swine is uniformly induced by a 12-day course of cyclosporine A (CyA) across a two-haplotype class I disparity. Second kidney allografts, SLA-matched to the first donor, are accepted without additional immunosuppression, suggesting a systemic mechanism of tolerance. We studied the role of the thymus in tolerance to renal allografts in this model.
Affiliations
  • Harvard Medical SchoolTransplantation Biology Research Center, MGH, Boston

Citations

Yamada, K., Gianello, P., Ierino, F. L., Shimizu, A., Meehan, S., Colvin, R. B., & Sachs, D. H. (1997). Influence of the thymus on transplantation tolerance in miniature swine. Transplantation Proceedings, 29(1-2), 1076. https://hdl.handle.net/2078.5/191352 (Original work published 1997)