TOLERANCE to kidney allografts in miniature swine is uniformly induced by a 12-day course of cyclosporine A (CyA) across a two-haplotype class I disparity. Second kidney allografts, SLA-matched to the first donor, are accepted without additional immunosuppression, suggesting a systemic mechanism of tolerance. We studied the role of the thymus in tolerance to renal allografts in this model.
Affiliations
Harvard Medical SchoolTransplantation Biology Research Center, MGH, Boston
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Yamada, K., Gianello, P., Ierino, F. L., Shimizu, A., Meehan, S., Colvin, R. B., & Sachs, D. H. (1997). Influence of the thymus on transplantation tolerance in miniature swine. Transplantation Proceedings, 29(1-2), 1076. https://hdl.handle.net/2078.5/191352 (Original work published 1997)