Transplacental Cocaine Exposure: A Mouse Model Demonstrating Neuroanatomic and Behavioral Abnormalities
(1994) Journal of Child Neurology — Vol. 9, n° 3, p. 234-241 (1994)
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- Abstract
- Between 10% and 15% of infants born in urban America today have been exposed to cocaine in utero. clinical studies have suggested that impairment of brain growth is the single best marker of significant prenatal cocaine exposure, and postnatal developmental compromised seen in a subset of affected children as a consequence of that exposure. We have developed an animal model, in mice, of prenatal cocaine exposure that has allowed us to dissociate the direct effects of cocaine in altering fetal development from the indirect effects associated with cocaine-induced malnutrition. We find that transplacental cocaine exposure independently impairs fetal brain and body growth and results in behavioural deficits and permanent alterations in neocortical cytoarchitecture in exposed offspring.
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Citations
Kosofsky, B. E., Wilkins, A. S., Gressens, P., & Evrard, P. (1994). Transplacental Cocaine Exposure: A Mouse Model Demonstrating Neuroanatomic and Behavioral Abnormalities. Journal of Child Neurology, 9(3), 234-241. https://doi.org/10.1177/088307389400900303 (Original work published 1994)