Although hypoxia has been long recognized as a crucial factor impairing tumor response in many therapeutic schemes, atraumatic and reliable methods of individually quantifying tumor oxygenation are still lacking in day-to-day clinical practice. The aim of this work was to investigate the potentially quantitative properties of our recently described noninvasive magnetic resonance (MR) technique "MOBILE" (mapping of oxygen by imaging lipids relaxation enhancement) and to qualify this endogenous contrast as a tumor hypoxia marker.
Colliez, F., Neveu, M.-A., Magat, J., Cao Pham, T. T., Gallez, B., & Jordan, B. (2014). Qualification of a noninvasive magnetic resonance imaging biomarker to assess tumor oxygenation. Clinical Cancer Research, 1(20), 5403-5411. https://doi.org/10.1158/1078-0432.CCR-13-3434 (Original work published 2014)