Dibekacin assay in serum by automated fluorescence polarization immunoassay (Abbott Tdx): Comparison with high-performance liquid chromatography, substrate-labelled fluorescent immunoassay and radioimmunoassay.

Rollmann, Bruno;Van Der Auwera, P;Tulkens, Paul M.
(1986) Journal of Pharmaceutical and Biomedical Analysis — Vol. 4, n° 1, p. 53-61 (1986)

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  • Rollmann, BrunoUCLouvain
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  • Van Der Auwera, P
    Author
  • Tulkens, Paul M.UCLouvain
    Author
Abstract
An immunoassay based on fluorescence polarization detection (FPIA) has been recently adapted for dibekacin. This has been compared with a reference method (high-performance liquid chromatography), and two other methods used in clinical laboratories for monitoring this aminoglycoside, namely substrate-labelled fluorescent immunoassay (SLFIA) and radioimmunoassay (RIA). FPIA was fast and more reliable than SLFIA or RIA, and offered therefore superior performance. However, its nominal cost per assay is high.
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Rollmann, B., Van Der Auwera, P., & Tulkens, P. M. (1986). Dibekacin assay in serum by automated fluorescence polarization immunoassay (Abbott Tdx): Comparison with high-performance liquid chromatography, substrate-labelled fluorescent immunoassay and radioimmunoassay. Journal of Pharmaceutical and Biomedical Analysis, 4(1), 53-61. https://doi.org/10.1016/0731-7085(86)80023-1 (Original work published 1986)