Biological image-guided radiotherapy requires that PET accurately identifies biologically relevant sub-volumes within a tumor. In this framework, an immobilization device was developed to study multi-imaging (CT, micro-MRI, micro-PET, and autoradiography) registration of mouse tumors. The registration accuracy assessed by calculating the average minimal distance between two skew lines was in the order of 0.2-0.3mm.
Christian, N., Lee, J., Bol, A., De Bast, M., Gallez, B., & Grégoire, V. (2008). Immobilization device for in vivo and in vitro multimodality image registration of rodent tumors. Radiotherapy & Oncology, 87(1), 147-151. https://doi.org/10.1016/j.radonc.2008.02.016 (Original work published 2008)