2,6-diamino-3,5-diaryl-1,4-pyrazine derivatives as novel antioxidants
(2001) Synthesis : journal of synthetic organic chemistry — n° 5, p. 768-772 (2001)
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- Abstract
- The coupling of arylboronic acids with 2,6-diamino-3,5-dibromo-1,4-pyrazine (6) gave 2,6-diamino-3,5-diaryl-1,4-pyrazines (7). The reaction of 7 with methyl glyoxal in aqueous EtOH-HCl led to the N,N'-disubstituted products 8, instead of the expected bicyclic imidazolopyrazinones 1. The 2,6-bis[1-(ethoxycarbonyl)ethylamino]-3,5-diaryl-1,4-pyrazines 8 are powerful inhibitors of the AAPH-induced linoleate peroxidation.
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Cavalier, J., Burton, M., De Tollenaere, C., Dussart, F., Marchand, C., Rees, J.-F., & Marchand-Brynaert, J. (2001). 2,6-diamino-3,5-diaryl-1,4-pyrazine derivatives as novel antioxidants. Synthesis : journal of synthetic organic chemistry, 5, 768-772. https://doi.org/10.1055/s-2001-12764 (Original work published 2001)