Toxoplasmoses congénitales et séroconversions de fin de grossesse: observations cliniques
(1997) Acta Clinica Belgica — Vol. 52, n° 6, p. 381-387 (1997)
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- (en) [Congenital toxoplasmosis and seroconversion at the end of pregnancy: clinical observations]. We report seven cases of subclinical congenital toxoplasmosis secondary to maternal primary infections. Mothers were infected between two and four weeks prior to delivery. The diagnostic criteria of congenital infections included: IgM antibody (Ab) (1 case); IgM and IgA Ab (1 case); a real IgG seroconversion in the neonatal and postnatal samples (3 cases); persistence of IgG Ab beyond 6 months post-delivery (2 cases). A treatment was initiated, including a combination of pyrimethamine + sulfadiazine (6 cases); trimethoprim + sulfamethoxazole (1 case). This retrospective study suggests that it is important to screen the non-immune pregnant women until delivery. We confirmed the usefulness of a combination of isotypes of antibodies for the accurate assessment of congenital infection. Finally, infected infants have to be treated and monitored clinically and immunologically during the first year of life.
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Luyasu, V., Bauraind, O., Bernard, P., Bietlot, Y., Brasseur, C., Englebert, J., Fiasse, L., Givron, O., Longueville, E., Melard, J.-L., Michel, M., & Wacquez, M. (1997). Toxoplasmoses congénitales et séroconversions de fin de grossesse: observations cliniques. Acta Clinica Belgica, 52(6), 381-387. https://doi.org/10.1080/17843286.1997.11718604 (Original work published 1997)