The Calcium-channel Blocker Nifedipine Fails To Inhibit Leukocyte Elastase Release During Cardiopulmonary Bypass

Massaut, J.;Hennebert, N.;Tasiaux, N.;Demanet, H.
(1993) Acta Anaesthesiologica Scandinavica : an international journal of anaesthesiology and intensive care, pain and emergency medicine — Vol. 37, n° 1, p. 82-84 (1993)

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  • Massaut, J.
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  • Hennebert, N.
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  • Tasiaux, N.
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  • Demanet, H.
    Author
Abstract
Circulating concentrations of leucocyte elastase were measured in 16 adult patients undergoing cardiopulmonary bypass (CPB) with a flat-sheet membrane oxygenator. Eight patients (Group I) received the calcium channel blocker nifedipine 9 mug.kg-1.h-1) during CPB. Eight patients (Group II) did not receive any calcium channel blocker during surgery and served as the control group. Elastase concentrations were measured at 7 time points: 2 before, 2 during, and 3 after CPB. The bypass procedure was associated with elevation in elastase concentrations (P < 0.001). Comparing to baseline values elastase concentrations were significantly elevated (P < 0.05) 60 min after the start of CPB and on all measurements done after CPB. Elastase concentrations correlated with the duration of CPB (rs = 0.76, P < 0.001), and were not influenced by nifedipine infusion as revealed by comparing the two groups. This study demonstrates moderate elastase release during CPB with a flat-sheet membrane oxygenator and fails to confirm inhibition of elastase release by nifedipine infusion during CPB.
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Massaut, J., Hennebert, N., Tasiaux, N., & Demanet, H. (1993). The Calcium-channel Blocker Nifedipine Fails To Inhibit Leukocyte Elastase Release During Cardiopulmonary Bypass. Acta Anaesthesiologica Scandinavica : an international journal of anaesthesiology and intensive care, pain and emergency medicine, 37(1), 82-84. https://doi.org/10.1111/j.1399-6576.1993.tb03604.x (Original work published 1993)