Delayed graft function and chronic allograft nephropathy: diagnostic and prognostic role of neutrophil gelatinase-associated lipocalin.

Lacquaniti, Antonio;Caccamo, Chiara;Salis, Paola;Chirico, Valeria;David, Antonio;et.al.
(2016) Biomarkers — Vol. 21, n° 4, p. 371-378 (2016)

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Authors
  • Lacquaniti, Antonio
    Author
  • Caccamo, Chiara
    Author
  • Salis, Paola
    Author
  • Chirico, Valeria
    Author
  • Buemi, AntoineUCLouvain
    Author
  • David, Antonio
    Author
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Abstract
(en) CONTEXT: Available markers are not reliable parameters to early detect kidney injury in transplanted patients. OBJECTIVE: Examine neutrophil gelatinase associated lipocalin (NGAL) in early detection of delayed graft function (DGF) and as a long-term predictor of graft outcome. PATIENTS AND METHODS: NGAL was evaluated in 124 transplanted patients. RESULTS: Urinary NGAL levels were associated to a 10% (HR: 1.10; 95% CI: 1.04-1.25; p < 0.001) and 15% (HR: 1.15; 95% CI: 1.09-1.26; p < 0.001) increased risk of DGF and allograft nephropathy progression, respectively. CONCLUSION: NGAL reflects the entity of renal impairment in transplanted patients, representing a biomarker and an independent risk factor for DGF and chronic allograft nephropathy progression.
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Lacquaniti, A., Caccamo, C., Salis, P., Chirico, V., Buemi, A., Cernaro, V., Noto, A., Pettinato, G., Santoro, D., Bertani, T., Buemi, M., & David, A. (2016). Delayed graft function and chronic allograft nephropathy: diagnostic and prognostic role of neutrophil gelatinase-associated lipocalin. Biomarkers, 21(4), 371-378. https://doi.org/10.3109/1354750X.2016.1141991 (Original work published 2016)