Diagnostic Challenges of Behçet Disease – Focus on Neurological Involvement (Neuro- Behçet) A Case Report
(2025) Frontiers in Medical Case Reports — Vol. 06, n° 05, p. 1-11 (2025)
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- Abstract
- Behçet’s disease (BD) is a rare multisystem inflammatory disorder first described in 1937 by Turkish dermatologist Hulusi Behçet. It is classically defined by a triad of recurrent oral aphthous ulcers, genital ulcers, and uveitis. Multiple studies have shown that BD can affect other organs, including the skin, joints, gastrointestinal tract, central nervous system, and blood vessels, and is therefore classified as a systemic vasculitis. The highest prevalence is found along the ancient Silk Road, covering the Middle East, Mediterranean basin, and Far East. We report the case of a 23-year-old man with BD presenting with recurrent fever, cognitive decline, lower extremity vein thrombosis, uveitis, and urinary retention. Despite those signs, the diagnosis was significantly delayed due to confounding factors, including a maternal Factor II mutation and a context of cannabis use. A comprehensive medical history including targeted questions about recurrent oral and genital ulcers led to the consideration of BD. This case underscores the importance of detailed clinical history-taking-particularly regarding mucocutaneous symptoms-and highlights both the value and limitations of International Criteria for Behçet’s Disease (ICBD) in complex, multisystem presentations.
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Kulicka, K., Pothen, L., Gunes Tatar, I., Chapusette, R., & M. Colin, I. (2025). Diagnostic Challenges of Behçet Disease – Focus on Neurological Involvement (Neuro- Behçet) A Case Report. Frontiers in Medical Case Reports, 06(05), 1-11. https://doi.org/10.47746/fmcr.2025.6501 (Original work published 2025)