Double diffusion encoding for probing the microstructure of tissues in magnetic resonance imaging : investigations on the clinical feasibility and application to experimental tumors
(2020)
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- Abstract
- Diffusion MRI is a medical imaging technique allowing to probe the microstructure of biological tissues, non-invasively. It is based on the mobility of water molecules between and within cells. In this context, double diffusion encoding is a novel method that could improve the sensibility to features of cell microenvironments. For instance, this would include mean cell size, cell density or microvascular perfusion. The main objective of the thesis is to implement a double diffusion encoding sequence on a clinical MR system in order to assess its feasibility. Furthermore, we apply the method to experimental tumors undergoing radiotherapy with the aim of validating its outcomes with histology. Finally, we investigate the added value of double diffusion encoding compared to alternative diffusion MRI techniques existing for tumors.
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Citations
Duchêne, G. (2020). Double diffusion encoding for probing the microstructure of tissues in magnetic resonance imaging : investigations on the clinical feasibility and application to experimental tumors. https://hdl.handle.net/2078.5/120217