The 5-acylamino-3-acetylhydantoin derivatives 8 were designed as potential antibiotics mimicking lactivicin 1. The racemic compounds 19a-c, prepared in six steps from 5-oxohydantoin, were inactive onto bacterial tests.
Marchand-Brynaert, J., Amadei, E., & Ghosez, L. (1994). Functionalized Hydantoins As Potential Antibiotics. Societes Chimiques Belges. Bulletin, 103(5-6), 213-218. https://doi.org/10.1002/bscb.19941030508 (Original work published 1994)