Efficient one-step synthesis of chiral bidentate oxazoline-alcohol ligands via a cyclic imidate ester rearrangement
(2009) Tetrahedron: Asymmetry — Vol. 20, n° 17, p. 1962-1968 (2009)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- Various chiral bidentate oxazoline-alcohol ligands were obtained in a straightforward one-step synthesis via a cyclic imidate ester rearrangement. These chiral ligands were tested and compared in asymmetric diethylzinc additions to aldehydes resulting in selectivities of up to 87% ee. An interesting chirality switch was observed when a CPh2-tether instead of a CH2 was present, offering the opportunity for dual stereocontrol. © 2009 Elsevier Ltd. All rights reserved.
- Affiliations
KU LEUVEN Department of Chemistry
Citations
Noël, T., Robeyns, K., Van Meervelt, L., Van der Eycken, E., & Van der Eycken, J. (2009). Efficient one-step synthesis of chiral bidentate oxazoline-alcohol ligands via a cyclic imidate ester rearrangement. Tetrahedron: Asymmetry, 20(17), 1962-1968. https://doi.org/10.1016/j.tetasy.2009.07.038 (Original work published 2009)