Sister chromatid exchanges in human peripheral blood lymphocytes after ingestion of high doses of arsenicals

Hantson, Philippe;Dumoulin, Christine;Libouton, Jeanne-Marie;Leonard, A.;Mahieu, P.;et.al.
(1996) International Archives of Occupational and Environmental Health — Vol. 68, n° 5, p. 342-344 (1996)

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Abstract
Objective-To evaluate the cytogenetic effects following the ingestion of high doses of arsenicals. Methods - Determination of the mean sister chromatid exchange (SCE) frequency and the population of high-frequency cells (HFC, cells with a high SCE frequency) in the peripheral blood lymphocytes in four patients who ingested 150 mg KAsO2, 1 g, 10 g and 20 g As2O3 respectively. Results-Doses of 10 g and 20 g significantly increased the HFC frequency and produced a shift in the distribution of the cells in accordance with the number of SCEs. The mean frequency of SCEs/cell was affected only after the highest dose (20 g). Conclusion-These results strongly suggest that cytogenetic methods are inappropriate for biomonitoring people occupationally exposed to arsenicals.
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Hantson, P., Dumoulin, C., Libouton, J.-M., Leonard, A., Leonard, ED., & Mahieu, P. (1996). Sister chromatid exchanges in human peripheral blood lymphocytes after ingestion of high doses of arsenicals. International Archives of Occupational and Environmental Health, 68(5), 342-344. https://doi.org/10.1007/BF00409420 (Original work published 1996)