Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection.
(2003) FEBS Letters — Vol. 544, n° 1-3, p. 214-217 (2003)
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- Authors
Thissen, Jean-Paul 
- Abstract
- MafBx and Murf are two new rat E3 ubiquitin ligases induced in muscle atrophy. Our goal was to investigate whether lipopolysaccharide (LPS) injection, a model of muscle catabolism, is associated with increased expression of MafBx and Murf. LPS (750 microg/100 g body weight) induces MafBx and Murf mRNA (respectively, 23-fold and 33-fold after 12 h; P<0.001). A transient induction of tumor necrosis factor-alpha mRNA (21-fold; P<0.001 at 3 h) and a decrease of insulin like growth factor-I mRNA (50%; P<0.001 at 6 h), two potential regulators of the ubiquitin-proteasome system were also demonstrated. In summary, MafBx and Murf mRNA are up-regulated in response to LPS and might play a role in the muscle proteolysis observed.
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Citations
Dehoux, M. J. M., Van Beneden, R., Fernández-Celemín, L., Lause, P., & Thissen, J.-P. (2003). Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection. FEBS Letters, 544(1-3), 214-217. https://doi.org/10.1016/S0014-5793(03)00505-2 (Original work published 2003)