Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198.
(1992) Immunogenetics — Vol. 35, n° 5, p. 316-323 (1992)
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- Abstract
- Tum- comprises a class of genes, mutation of which in P815 tumor cells has led to the acquisition of new cytotoxic T cell-recognized epitopes. The cells carrying the mutant alleles have impaired tumorigenicity compared with their progenitors due to in vivo induction of a cytotoxic T-cell response specific for tum- antigens. Two tum- genes, P91A and P35B, were found to be single copy loci mapping to chromosomes 11 and 15 respectively. A third, P198, was found to map to chromosome 7 and to be a member of a small gene family with other members on chromosomes 13, 14, and 15. Multiple P198-related sequences were found in other mammalian species suggesting the P198 related gene family is a general feature of mammalian genomes.
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Citations
Dyson, P. J., De Smet, C., Knight, A. M., Simon-Chazottes, D., Guénet, J. L., & Boon, T. (1992). Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198. Immunogenetics, 35(5), 316-323. https://hdl.handle.net/2078.5/51000 (Original work published 1992)