PMSC differentiation induced by musculoskeletal matrix: In vitro study

Manon, Julie;Evrard, Robin;Maistriaux, Louis;Fievé, Lies;Cornu, Olivier;et.al.
(2023) The International Combined Orthopaedic Research Societies (ICORS), World Congress of Orthopaedic Research — Location: (Scotland) Edinburgh (7.September.2022)

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Abstract
Periosteal mesenchymal stem cells (PMSC) are an emerging niche of stem cells to enhance bone healing by tissue engineering process. They have to be differentiated into osteoprogenitors in order to synthesize new bone matrix. In vitro differentiation with specific differentiation medium (DM) is not exactly representative of what occurs in vivo. The interaction between PMSC and growth factors (GF) present in biological matrix is somewhat less understood. The goal of this study is to explore the possibility of spontaneous PMSC differentiation in contact with different biological matrices without DM. [...]
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Manon, J., Evrard, R., Maistriaux, L., Fievé, L., de Ville de Goyet, C., Vanham, P., Schubert, T., Gianello, P., Lengelé, B., Behets Wydemans, C., & Cornu, O. (2023). PMSC differentiation induced by musculoskeletal matrix: In vitro study. Journal of Bone and Joint Surgery. British Volume. Orthopaedic Proceedings, 105-B(SUPP_8), 10. https://doi.org/10.1302/1358-992x.2023.8.010 (Original work published 2023)