This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein turnover, mitochondrial biogenesis, and whole-body energy homeostasis. AMPK acts as whole-body energy sensor and integrates different signaling pathway to meet both cellular and body energy requirements while inhibiting energy-consuming processes but also activating energy-producing ones. AMPK mainly promotes glucose and fatty acid catabolism, whereas it prevents protein, glycogen, and fatty acid synthesis.
Angin, Y., Beauloye, C., Horman, S., & Bertrand, L. (2022). Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK. Experientia supplementum (2012), 107(1), 23-43. https://doi.org/10.1007/978-3-319-43589-3_2 (Original work published 2022)