Exploring the biodegradability of candidate metallic intravascular stent materials using X-ray microfocus computed tomography: An in vitro study

Leyssens, Lisa;Lapraille, Noémie;Pyka, Grzegorz;Jacques, Pascal;Kerckhofs, Greet;et.al.
(2024) Journal of Biomedical Materials Research. Part B: Applied Biomaterials — Vol. 112, n° 8, p. e35452 (2024)

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In vitro testing for evaluating degradation mode and rate of candidate biodegradable metals to be used as intravascular stents is crucial before going to in vivo animal models. In this study, we show that X-ray microfocus computed tomography (microCT) presents a key added value to visualize degradation mode and to evaluate degradation rate and material surface properties in 3D and at high resolution of large regions of interest. The in vitro degradation behavior of three candidate biodegradable stent materials was evaluated: pure iron (Fe), pure zinc (Zn), and a quinary Zn alloy (ZnAgCuMnZr). These metals were compared to a reference biostable cobaltchromium (CoCr) alloy. To compare the degradation mode and degradation rate evaluated with microCT, scanning electron microscopy (SEM) and inductively-coupled plasma (ICP) were included. We confirmed that Fe degrades very slowly but with desirable uniform surface corrosion. Zn degrades faster but exhibits localized deep pitting corrosion. The Zn alloy degrades at a similar rate as the pure Zn, but more homogeneously. However, the formation of deep internal dendrites was observed. Our study provides a detailed microCT-based comparison of essential surface and corrosion properties, with a structural characterization of the corrosion behavior, of different candidate stent materials in 3D in a non-destructive way.
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Leyssens, L., Lapraille, N., Pyka, G., Jacques, P., Horman, S., Goldman, J., & Kerckhofs, G. (2024). Exploring the biodegradability of candidate metallic intravascular stent materials using X-ray microfocus computed tomography: An in vitro study. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 112(8), e35452. https://doi.org/10.1002/jbm.b.35452 (Original work published 2024)