The Knudson's two-hit phenomenon and timing of somatic mutation may account for the phenotypic diversity of focal congenital hyperinsulinism

Giurgea, I., Sempoux, C., Chantelot, C. B., Hubert, L., Brunelle, F., Robert, J. J., Fekete, C., & de Ionlay, P. (2006). The Knudson’s two-hit phenomenon and timing of somatic mutation may account for the phenotypic diversity of focal congenital hyperinsulinism. Hormone Research, 65, 18. https://doi.org/10.1159/000090375 (Original work published 2006)