The first bremsstrahlung imaging was performed early 1966 by Simon et al. [1, 2] using a rectilinear scanner following a liver radioembolisation via the hepatic artery with 90Y loaded 15 μm diameter microspheres. Although of very low quality, this imaging already provided the main information: the carcinoid tumours were well preferentially targeted (Fig. 13.1).
Walrand, S. (2014). Bremsstrahlung SPECT/CT. In Hojjat Ahmadzadehfar, Hans-Jürgen Biersack (ed.), Clinical Applications of SPECT-CT (p. p. 271-280). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-35283-6_13