Therapeutic hopes for CFTR-related recurrent pancreatitis: a case-series
(2026) Journal of Cystic Fibrosis — (2026)
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- Authors
Le, Anaïs 
Scheers,Isabelle
- Abstract
- The presence of CFTR variants increases the risk of pancreatitis in pancreatic sufficient people with cystic fibrosis (pwCF) or with CFTR-related disorder (pwCFTR-RD). Modulators have been showed to decrease pancreatitis episodes in pwCF presenting recurrent pancreatitis. Whether CFTR modulators are efficient to prevent recurrent episodes of pancreatitis in pwCFTR-RD is not known. We collected clinical, biological, imaging and CFTR functional data in 4 patients with recurrent pancreatitis and CFTR-RD, treated with CFTR modulators and assessed the efficacy of the treatment. With a follow-up of minimum 9 months, we found that ETI and ivacaftor reduced or even resolved the number of acute pancreatitis episodes.
- Affiliations
Citations
Gohy, S., Le, A., Sermet-Gaudelus, I., De Wachter, E., Lhomme, A., Vermeulen, F., & Scheers, I. (2026). Therapeutic hopes for CFTR-related recurrent pancreatitis: a case-series. Journal of Cystic Fibrosis. Submitted. https://doi.org/10.1016/j.jcf.2026.02.008 (Original work published 2026)