Myelodysplastic syndrome with monosomy 5 and/or 7 following therapy with 2-chloro-2'-deoxyadenosine.
(1999) British Journal of Haematology — Vol. 105, n° 1, p. 268-270 (1999)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- A few cases of secondary neoplasms occurring after treatment with 2-chloro-2'-deoxyadenosine (2CdA) have been reported, mostly in patients previously exposed to other anti-cancer drugs including alkylating agents (AA). Here we report on the occurrence of a myelodysplastic syndrome (MDS) with monosomy 5 and/or 7 in two patients after 2CdA treatment, without or prior to other toxic exposure. In light of a literature review and given the involvement of chromosomes frequently abnormal in secondary leukaemias, we suggest that 2CdA may induce therapy-related MDS (t-MDS).
- Affiliations
Citations
Van Den Neste, E., Louviaux, I., Michaux, J.-L., Delannoy, A., Michaux, L., Hagemeijer, A., Scheiff, J.-M., Bosly, A., Straetmans, N., & Ferrant, A. (1999). Myelodysplastic syndrome with monosomy 5 and/or 7 following therapy with 2-chloro-2′-deoxyadenosine. British Journal of Haematology, 105(1), 268-270. https://hdl.handle.net/2078.5/51939 (Original work published 1999)