Standardization of pre-analytical variables in plasma microparticle determination: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop.

Lacroix, Romaric;Judicone, Coralie;Mooberry, Micah;Boucekine, Mohamed;Mullier, François;et.al.
(2013) Journal of Thrombosis and Haemostasis — Vol. 11, n° 6, p. 1190-1193 (2013)

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Authors
  • Lacroix, Romaric
    Author
  • Judicone, Coralie
    Author
  • Mooberry, Micah
    Author
  • Boucekine, Mohamed
    Author
  • Bailly, NicolasUCLouvain
    Collaborator
  • Mullier, FrançoisUCLouvain
    Collaborator
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Abstract
Microparticles (MP) are sub-micron sized vesicles released by activated or apoptotic cells. They are generally defined as 0.1 to 1 μm membrane particles that expose the anionic phospholipid phosphatidylserine (PS) and membrane antigens representative of their cellular origin [1]. It is now well recognized that MP behave as vectors of bioactive molecules, playing a role in blood coagulation, inflammation, cell activation and cancer metastasis. In clinical practice, circulating MP originating from blood and vascular cells are elevated in a variety of prothrombotic and inflammatory disorders, cardiovascular diseases, autoimmune conditions, infectious diseases and cancer [1-3]
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Lacroix, R., Judicone, C., Mooberry, M., Boucekine, M., Key, N. S., Dignat-George, F., & The ISTH SSC Workshop. (2013). Standardization of pre-analytical variables in plasma microparticle determination: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop. Journal of Thrombosis and Haemostasis, 11(6), 1190-1193. https://doi.org/10.1111/jth.12207 (Original work published 2013)