Synthesis of C5-substituted imidazolines
(2003) Tetrahedron Letters — Vol. 44, n° 51, p. 9111-9114 (2003)
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- 5-(Hydroxymethyl)-3-(t-butyloxycarbonyl)imidazoline 2 was prepared in four steps from 2,3-diaminopropionic acid in 72% overall yield. Mitsunobu reaction with a series of phenol derivatives gave the corresponding 5-(aryloxymethyl)-3-(t-butyloxycarbonyl)imidazolines 8a-1. Phthalimide and N-benzyl trifluoroacetamide also reacted. (C) 2003 Elsevier Ltd. All rights reserved.
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Defacqz, N., Van, TT., Cordi, A., & Marchand-Brynaert, J. (2003). Synthesis of C5-substituted imidazolines. Tetrahedron Letters, 44(51), 9111-9114. https://doi.org/10.1016/j.tetlet.2003.10.044 (Original work published 2003)