Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function.
(2023) Cardiovascular Research — Vol. 119, n° 14, p. 2390-2404 (2023)
Files
cvad088.pdf
Open Access - Adobe PDF
- 2.68 MB
Details
- Authors
Ciccarelli, Michele 
Bauersachs, Johann
- Abstract
- While chronic heart failure (CHF) treatment has considerably improved patient prognosis and survival, the therapeutic management of acute heart failure (AHF) has remained virtually unchanged in the last decades. This is partly due to the scarcity of pre-clinical models for the pathophysiological assessment and, consequently, the limited knowledge of molecular mechanisms involved in the different AHF phenotypes. This scientific statement outlines the different trajectories from acute to CHF originating from the interaction between aetiology, genetic and environmental factors, and comorbidities. Furthermore, we discuss the potential molecular targets capable of unveiling new therapeutic perspectives to improve the outcome of the acute phase and counteracting the evolution towards CHF.
- Affiliations
Citations
Ciccarelli, M., Pires, I. F., Bauersachs, J., Bertrand, L., Beauloye, C., Dawson, D., Hamdani, N., Hilfiker-Kleiner, D., van Laake, L. W., Lezoualc’h, F., Linke, W. A., Lunde, I. G., Rainer, P. P., Rispoli, A., Visco, V., Carrizzo, A., Ferro, M. D., Stolfo, D., van der Velden, J., et al. (2023). Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function. Cardiovascular Research, 119(14), 2390-2404. https://doi.org/10.1093/cvr/cvad088 (Original work published 2023)