La tuberculose : épidémiologie, aspect clinique et traitement
(2015) Louvain médical — Vol. 134, n° 10, p. 549-559 (2015)
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- (en) [Tuberculosis: epidemiology, clinical aspects, and treatment] Tuberculosis (TB) is a contagious infectious disease caused by members of the mycobacterium tuberculosis complex, and mainly by mycobacterium tuberculosis. TB has been observed for over 120 centuries. In 2013, an estimated 9 million people contracted the disease and 1.5 million people died from it, including 360,000 HiV-positive subjects. The epidemic is now characterized by an increase in multiresistant strains. A distinction can be made between pulmonary TB, the most common presentation (70-75% of cases), and extrapulmonary TB. In immunocompromised patients, more profound immunosuppression is associated with non-cavitary, extrapulmonary, and especially disseminated TB forms. Molecular techniques have greatly modified the diagnostic arsenal. while providing diagnostic results within 2 to 24 hours with a good sensitivity and specificity, these techniques are also sensitive to both rifampicin and isoniazid, which is useful for diagnosing the multidrug-resistant forms. The treatment is based on a combination of four first-line anti-TB agents, i.e., isoniazid, rifampicin, pyrazinamide, and ethambutol
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Yombi, J. C., & Olinga Medjo, U. (2015). La tuberculose : épidémiologie, aspect clinique et traitement. Louvain médical, 134(10), 549-559. https://hdl.handle.net/2078.5/184183 (Original work published 2015)