Effects of Short Term Treatment with metformin on serul concentrations of homocysteine, folate and vitamin B12 in type 2 diabetus mellitus: A randomised, Placebo controlled Trial,

Wulffele, M.;Stehouwer, C;Donker, A;Bets, D.;Kooy, A;et.al.
(2003) Journal of Internal Medicine : from genes and molecules to patients — Vol. 254 (2003)

Files

No attached file found for this publication.

Details

Authors
  • Wulffele, M.
    Author
  • Stehouwer, C
    Author
  • Donker, A
    Author
  • Bets, D.
    Author
  • Kooy, A
    Author
Show more
Abstract
(en) We investigated whether metformin affects serum concentrations of homocysteine, folate and vitamin B12 in subjects with type 2 diabetes treated with insulin. Design. Placebo-controlled, randomized trial. Measurements: at baseline and 16 weeks later. Setting. A total of 745 patients with type 2 diabetes, treated with insulin were approached; Addition of metformin or placebo to insulin therapy. Primary outcome parameters. Serum homocysteine, folate, vitamin B12, indices of glycaemic control and body weight. Results. metformin use, as compared with placebo, was associated with an increase in homocysteine of 4% (0.2 to 8; P ¼ 0.039) and with decreases in folate [)7% ()1.4 to )13); P ¼ 0.024] and vitamin B12 [)14% ()4.2 to )24); P < 0.0001]. In patients with type 2 diabetes, 16 weeks of treatment with metformin reduces levels of folate and vitamin B12, which results in a modest increase in homocysteine. The clinical significance of these findings remains to be investigated.
Affiliations
  • Louvain School of Management

Citations

  • APA
  • Chicago
  • FWB

Wulffele, M., Stehouwer, C., Donker, A., Bets, D., Lehert, P., & Kooy, A. (2003). Effects of Short Term Treatment with metformin on serul concentrations of homocysteine, folate and vitamin B12 in type 2 diabetus mellitus: A randomised, Placebo controlled Trial,. Journal of Internal Medicine : from genes and molecules to patients, 254. https://hdl.handle.net/2078.5/128522 (Original work published 2003)