Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients.

Elens, Laure;Vandercam, Bernard;Yombi, Jean Cyr;Lison, Dominique;Haufroid, Vincent;et.al.
(2011) Pharmacogenomics — Vol. 11, n° 9, p. 1223-1234 (2010)

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Abstract
Efavirenz (EFV) is characterized by interindividual pharmacokinetic variability causing inconsistent clinical responses. Previous studies have identified some possible genetic determinants of the variability in plasma concentrations. However, their impact on EFV intracellular pharmacokinetics remains mostly unexplored.
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Elens, L., Vandercam, B., Yombi, J. C., Lison, D., Wallemacq, P., & Haufroid, V. (2011). Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. Pharmacogenomics, 11(9), 1223-1234. https://doi.org/10.2217/pgs.10.94 (Original work published 2010)