Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system.

Houssiau, Frédéric;Bukasa, K.;Sindic, Christian;Van Damme, Julie;Van Snick, Jacques
(1988) Clinical and Experimental Immunology — Vol. 71, n° 2, p. 320-323 (1988)

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Authors
  • Houssiau, FrédéricUCLouvain
    Author
  • Bukasa, K.
    Author
  • Sindic, ChristianUCLouvain
    Author
  • Van Damme, JulieUCLouvain
    Author
  • Van Snick, JacquesUCLouvain
    Author
Abstract
We reported recently that a human protein, previously described as IL-1 inducible 26K factor (26K) or interferon-beta 2, was a potent growth factor for B cell hybridomas in vitro. Subsequently, it appeared that this protein was also identical with the lymphokine B cell stimulatory factor 2. Here we report that the levels of 26K are considerably increased during the early stages of acute infections of the central nervous system. This elevation in 26K titres was not observed in either chronic infections or in non-infectious diseases.
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Citations

Houssiau, F., Bukasa, K., Sindic, C., Van Damme, J., & Van Snick, J. (1988). Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clinical and Experimental Immunology, 71(2), 320-323. https://hdl.handle.net/2078.5/80334 (Original work published 1988)