Comparison of Gadolinium-dtpa and Polylysine-gadolinium-dtpa - Enhanced Magnetic-resonance-imaging of Hepatocarcinoma in the Rat
(1995) Investigative Radiology : a journal of clinical and laboratory research — Vol. 30, n° 10, p. 572-581 (1995)
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- Abstract
- RATIONALE AND OBJECTIVES. TO compare the magnetic resonance (MR) imaging characteristics of gadolinium-DTPA (Gd-DTPA), a low-molecular-weight contrast agent, and polylysine-Gd-DTPA, a macromolecular contrast agent, in two types of hepatocarcinomas (HCC) in the rat. METHODS. T1-weighted spin-echo images were obtained in 13 rats with chemically induced HCC and 26 rats with Novikoff HCC before and 3 minutes to 60 hours after administration of either Gd-DTPA or polylysine-Gd-DTPA. RESULTS. Three minutes after polylysine-Gd-DTPA administration, the tumor-to-liver contrast of the two types of HCC increased significantly (positive contrast for chemically induced HCC and negative contrast for Novikoff HCC). At 30 minutes and 60 hours, the tumor-to-liver contrast remained above baseline values in chemically induced HCC and returned progressively to baseline values in Novikoff HCC. No significant increase in tumor-to-liver contrast was observed after Gd-DTPA administration. CONCLUSIONS. These results suggest that polylysine-Gd-DTPA provides a higher and more prolonged increase in tumor-to-liver contrast than Gd-DTPA.
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Grandin, C., Van Beers, B., Demeure, R., Goudemant, J.-F., Mottet, I., & Pringot, J. (1995). Comparison of Gadolinium-dtpa and Polylysine-gadolinium-dtpa - Enhanced Magnetic-resonance-imaging of Hepatocarcinoma in the Rat. Investigative Radiology : a journal of clinical and laboratory research, 30(10), 572-581. https://doi.org/10.1097/00004424-199510000-00002 (Original work published 1995)