A novel implantable vagus nerve stimulation system (ADNS-300) for combined stimulation and recording of the vagus nerve : pilot trial at Ghent University Hospital
(2010) Epilepsy Research — Vol. 92, n° 2-3, p. 231-239 (2010)
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- Abstract
- PURPOSE: Vagus nerve stimulation (VNS) is an established treatment for refractory epilepsy. The ADNS-300 is a new system for VNS that includes a rechargeable stimulus generator and an electrode for combined stimulation and recording. In this feasibility study, three patients were implanted with ADNS-300 for therapeutic VNS. In addition, compound action potentials (CAPs) were recorded to evaluate activation of the vagus nerve in response to VNS. METHODS: Three patients were implanted with a cuff-electrode around the left vagus nerve, that was connected to a rechargeable pulse generator under the left clavicula. Two weeks after surgery, therapeutic VNS (0.25-1.25 mA, 500 μs, 30s on, 10 min off and 30Hz) was initiated and stimulus-induced CAPs were recorded. RESULTS: The ADNS-300 system was successfully implanted in all three patients and patients were appropriately stimulated during six months of follow-up. A reduction in seizure frequency was demonstrated in two patients (43% and 40% in patients 1 and 3, respectively), while in patient 2 seizure frequency remained unchanged. CAPs could be recorded in patients 1 and 2, proving stimulation-induced activation of the vagus nerve. CONCLUSION: This feasibility study demonstrates that the ADNS-300 system can be used for combined therapeutic stimulation (in 3/3 patients) and recording of CAPs in response to VNS (in 2/3 patients) up to three weeks after surgery. Implantation in a larger number of patients will lead to a better understanding of the electrophysiology of the vagus nerve, which in turn could result in more adequate and individualized VNS parameter choice.
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El Tahry, R., Raedt, M., Mollet, L., De Herdt, V., Wyckuys, T., Van Dycke, A., Meurs, A., Dewaele, F., Van Roost, D., Doguet, P., Delbeke, J., Wadman, W., Vonck, K., & Boon, P. (2010). A novel implantable vagus nerve stimulation system (ADNS-300) for combined stimulation and recording of the vagus nerve : pilot trial at Ghent University Hospital. Epilepsy Research, 92(2-3), 231-239. https://doi.org/10.1016/j.eplepsyres.2010.10.007 (Original work published 2010)