Early prognostic factors in Complex Regional Pain Syndrome : a biopsychosocial investigation towards stratified and personalized management
(2025)
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- Abstract
- This thesis investigates early prognostic factors in Complex Regional Pain Syndrome (CRPS), a rare yet disabling condition marked by heterogeneity and unpredictable outcomes. Through a systematic review, a prospective cohort (n=113, <6 months onset), and a 1-year follow-up, it examined biological and psychosocial determinants of prognosis. Latent class analysis identified four biopsychosocial early profiles (BE-CRPS). Psychosocial factors (such as psychosocial severity) emerge as the strongest predictors of evolution, though allodynia retained predictive value. These findings demonstrate that prognosis in CRPS is largely shaped by biopsychosocial factors, support the feasibility of stratified management grounded in identified early profiles, and emphasize the need for validated prognostic tools to prevent chronification and guide personalized interventions.
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Citations
Louis, M.-H. (2025). Early prognostic factors in Complex Regional Pain Syndrome : a biopsychosocial investigation towards stratified and personalized management.