Anti-neutrophil antibodies in chronic hepatitis and the effect of alpha-interferon therapy.
(1993) Journal of Hepatology — Vol. 17, n° 3, p. 294-300 (1993)
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- Abstract
- In 34 patients with non-A non-B, 28 with type B and 11 with autoimmune chronic hepatitis, anti-neutrophil antibodies were investigated using indirect immunofluorescence and anti-myeloperoxidase antibodies by enzyme-linked immunosorbent assay. Granulocyte-specific antinuclear antibodies, were detected in 14 patients with advanced stages of non-A, non-B hepatitis (41%). Their presence correlated with histological features of disease activity but not with response to interferon therapy. Within 24 h after the first dose of interferon, 9 of these became negative and 3 more became negative after 1, 3 and 5 months. Myeloperoxidase-positive perinuclear neutrophil cytoplasmic antibodies were detected in a single patient and increased reaching a peak level after 8 weeks of interferon, decreasing thereafter. In type B, all were negative before and during the 6 months of therapy. In 6 patients with autoimmune hepatitis (55%), myeloperoxidase-negative perinuclear neutrophil cytoplasmic antibodies were detected in high titers. The association of granulocyte-specific anti-nuclear antibodies with non-A, non-B hepatitis support the hypothesis that hepatitis C virus infection might trigger humoral autoimmune response. In chronic autoimmune hepatitis, perinuclear neutrophil cytoplasmic antibodies appear as another marker of autoimmunity.
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Warny, M., Brenard, R., Cornu, C., Tomasi, JP., & Geubel, A. (1993). Anti-neutrophil antibodies in chronic hepatitis and the effect of alpha-interferon therapy. Journal of Hepatology, 17(3), 294-300. https://doi.org/10.1016/S0168-8278(05)80208-9 (Original work published 1993)