Molecular Modeling Studies On 11-beta-aminoethoxyphenyl and 7-alpha-aminoethoxyphenyl Estradiols - Evidence Suggesting a Common Hydrophobic Pocket in Estrogen-receptor

Poupaert, Jacques;Lambert, DM.;Vamecq, J.;Abulhajj, YJ.
(1995) Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 5, n° 8, p. 839-842 (1995)

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Authors
  • Poupaert, JacquesUCLouvain
    Author
  • Lambert, DM.
    Author
  • Vamecq, J.
    Author
  • Abulhajj, YJ.
    Author
Abstract
Molecular modeling studies were performed on 11 beta and 7 alpha-aminoethoxyphenyl estradiols to determine whether these compounds may interact with the same receptor subsite. Energy minimization and molecular dynamics studies lend support to this hypothesis.
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Poupaert, J., Lambert, DM., Vamecq, J., & Abulhajj, YJ. (1995). Molecular Modeling Studies On 11-beta-aminoethoxyphenyl and 7-alpha-aminoethoxyphenyl Estradiols - Evidence Suggesting a Common Hydrophobic Pocket in Estrogen-receptor. Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, 5(8), 839-842. https://doi.org/10.1016/0960-894X(95)00128-G (Original work published 1995)