Science is 1% inspiration and 99% biomarkers

Dubuisson, Nicolas;Puentes, Fabiola;Giovannoni, Gavin;Gnanapavan, Sharmilee
(2017) Multiple sclerosis (Houndmills, Basingstoke, England) — Vol. 23, n° 11, p. 1442-1452 (2017)

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Authors
  • Dubuisson, Nicolasorcid-logoUCLouvain
    Author
  • Puentes, FabiolaDepartment of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK.
    Author
  • Giovannoni, GavinDepartment of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK.
    Author
  • Gnanapavan, SharmileeDepartment of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK.
    Author
Abstract
Neurodegeneration plays a key role in multiple sclerosis (MS) contributing to long-term disability in patients. The prognosis is, however, unpredictable coloured by complex disease mechanisms which can only be clearly appreciated using biomarkers specific to pathobiology of the underlying process. Here, we describe six promising neurodegenerative biomarkers in MS (neurofilament proteins, neurofilament antibodies, tau, N-acetylaspartate, chitinase and chitinase-like proteins and osteopontin), critically evaluating the evidence using a modified Bradford Hill criteria.
Affiliations
  • Department of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK.

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Dubuisson, N., Puentes, F., Giovannoni, G., & Gnanapavan, S. (2017). Science is 1% inspiration and 99% biomarkers. Multiple sclerosis (Houndmills, Basingstoke, England), 23(11), 1442-1452. https://doi.org/10.1177/1352458517709362 (Original work published 2017)