Preliminary results of proton beam characterization for a facility of broad beam in vitro cell irradiation
(2008) 9th European Conference on Accelerators in Applied Research and Technology — Location: Florence(Italy) (3.September.2007)
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- Authors
Wéra, Anne-Catherine 
- Abstract
- The interaction of charged particles with living matter needs to be well understood for medical applications. Particularly, it is useful to study how ion beams interact with tissues in terms of damage, dose released and dose rate. One way to evaluate the biological effects induced by an ion beam is by the irradiation of cultured cells at a particle accelerator, where cells can be exposed to different ions at different energies and flux. In this paper, we report the first results concerning the characterization of a broad proton beam obtained with our 2 MV tandem accelerator. For broad beam in vitro cell irradiation, the beam has to be stable over time, uniform over a similar to 0.5 cm(2) surface, and a dose rate ranging from 0.1 to 10 Gy/min must be achievable. Results concerning the level of achievement of these requirements are presented in this paper for a 1 MeV proton beam. (C) 2008 Elsevier B.V. All rights reserved.
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Citations
Wéra, A.-C., Donato, K., Michlels, C., Jongen, Y., & Lucas, S. (2008). Preliminary results of proton beam characterization for a facility of broad beam in vitro cell irradiation. Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 266(10), 2122-2124. https://doi.org/10.1016/j.nimb.2008.02.066 (Original work published 2008)