Hepatitis C virus genotypes in hemodialyzed patients: a multicentric study
(1997) Clinical Nephrology — Vol. 47, n° 6, p. 367-371 (1997)
Files
13179.pdf
Restricted Access - Adobe PDF
- 2.05 MB
Details
- Authors
- Abstract
- The few studies concerning HCV genotypes in hemodialyzed patients concerned small groups of patients, issued from single units. Using the RFLP typing method in the 5' non-coding region (5' NCR), we performed the genotyping of HCV strains of 80 patients issued from 14 Belgian dialysis units. Forty-seven of the 80 patients were also tested by Inno-Lipa II (Innogenetics, Gent, Belgium). Sixty-four of 80 patients (80%) were infected with subtype 1b, 2 (2.5%) with subtype 1a, 6 (7.5%) with subtype 2a and 1 (1%) with subtype 2b; 6 patients (7.5%) showed a type 4 and 2 patients (2.5%) a type 5 infection, respectively. Only 1 patient (1%) showed a mixed infection (1a and 1b). In the 47 patients tested by both methods, we observed a very good agreement (98%) between RFLP and Inno-Lipa II's results. Our multicentric study detected HCV genotypes 4 or 5 in 8/80 (10%) of hemodialyzed patients in Belgium. The substantial prevalence of these genotypes could not be fully explained by a nosocomial spread of HCV infection: indeed, four patients belonged to dialysis units located in different cities, and two appeared infected with distinct subtypes in a same unit. Thus, the discovery of a "rare" HCV genotype in several hemodialyzed patients does not always point to nosocomial HCV transmission.
- Affiliations
Citations
Goessens, C., Jadoul, M., Walon, C., Burtonboy, G., & Cornu, C. (1997). Hepatitis C virus genotypes in hemodialyzed patients: a multicentric study. Clinical Nephrology, 47(6), 367-371. https://hdl.handle.net/2078.5/136780 (Original work published 1997)