La thérapie cellulaire du diabète : Le point sur les actualités
(2016) M/S : médecine sciences — Vol. 32, n° 4, p. 401-407 (2016)
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- (en) [Cellular therapy of diabetes: focus on the latest developments]. Islet transplantation has set the ground for diabetes cell therapy and is still undergoing various developments that might improve clinical outcomes. Alternative sources for β-cell replacement strategies are now led by human pluripotent stem cells that demonstrate near-normal β-cell features after in vitro differentiation and which can reverse diabetes in mice. Yet, their propensity for tumor formation is still unresolved. The adult pancreas is suggested as a reservoir of facultative progenitors that could represent adequate candidates for β-cell engineering, either in vivo through pharmacological treatment or after expansion in culture. This review focuses on the latest developments in protocols aiming at de novo production of functional β cells.
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Lysy, P. (2016). La thérapie cellulaire du diabète : Le point sur les actualités. M/S : médecine sciences, 32(4), 401-407. https://doi.org/10.1051/medsci/20163204019 (Original work published 2016)