Mice lacking factor VII develop normally but suffer fatal perinatal bleeding
(1997) Nature : international weekly journal of science — Vol. 390, n° 6657, p. 290-294 (1997)
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- Abstract
- Blood coagulation in vivo is initiated by factor VII (FVII) binding to its cellular receptor tissue factor (TF)(1-4). FVII is the only known ligand for TF, so it was expected that FVII-deficient embryos would have a similar phenotype to TF-deficient embryos, which have defective vitello-embryonic circulation and die around 9.5 days of gestation(5-8), Surprisingly, we find that FVII-deficient (FVII-/-) embryos developed normally, FVII-/- mice succumbed perinatally because of fatal haemorrhaging from normal blood vessels. At embryonic day 9.5, maternal-fetal transfer of FVII was undetectable and survival of embryos did not depend on TF-FVII-initiated fibrin formation. Thus, the TF-/- embryonic lethal and the FVII-/- survival-phenotypes suggest a role for TF during embryogenesis beyond fibrin formation.
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Rosen, E., Chan, J., Idusogie, E., Clotman, F., Vlasuk, G., Luther, T., Jalbert, L., Albrecht, S., Zhong, L., Lissens, A., Schoonjans, L., Moons, L., Collen, D., Castellino, F., & Carmeliet, P. (1997). Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Nature : international weekly journal of science, 390(6657), 290-294. https://doi.org/10.1038/36862 (Original work published 1997)