Regional localization of two genes for nonspecific X-linked mental retardation to Xp22.3-p22.2 (MRX49) and Xp11.3-p11.21 (MRX50)
(1997) American Journal of Medical Genetics — Vol. 73, n° 4, p. 474-479 (1997)
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- Abstract
- Two families with nonspecific X-linked mental retardation (XLMR) are presented, In the first family, MRX49, 5 male patients in 2 generations showed mild to moderate mental retardation, Two-point linkage analysis with 28 polymorphic markers, dispersed over the X-chromosome, yielded a maximal LOD score of 2.107 with markers DXS7107 and DXS8051 at theta = 0.0, localizing the MRX49 gene at Xp22.3-p22.2, between Xpter and marker DXS8022. Multipoint linkage analysis showed negative LOD values over all other regions of the chromosome. In the second family, MRX50, 4 males in 2 generations showed moderate mental retardation, Pairwise linkage analysis with 28 polymorphic markers yielded a LOD score of 2.056 with markers DXS8054, DXS1055, and DXS1204, all at theta = 0.0, Flanking markers were DXS8012 and DXS991, situating the MRX50 gene at Xp11.3-Xp11.21, in the pericentromeric part of the short arm of the X chromosome. (C) 1997 Wiley-Liss, Inc.
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Claes, S., Vogels, A., Holvoet, M., Devriendt, K., Raeymaekers, P., Cassiman, JJ., & Fryns, JP. (1997). Regional localization of two genes for nonspecific X-linked mental retardation to Xp22.3-p22.2 (MRX49) and Xp11.3-p11.21 (MRX50). American Journal of Medical Genetics, 73(4), 474-479. https://doi.org/10.1002/(SICI)1096-8628(19971231)73:4<474::AID-AJMG18>3.0.CO;2-O (Original work published 1997)