Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: A multicenter study
(2009) World Journal of Gastroenterology — Vol. 15, n° 13, p. 1587-1593 (2009)
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- AIM: To evaluate the ability of endoscopic ultrasound (EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes. METHODS: A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass (n = 121) or lymph node (n = 101). The classification as benign or malignant, based on the real time elastography pattern, was compared with the classification based on the B-mode EUS images and with the final diagnosis obtained by EUS-guided fine needle aspiration (EUS-FNA) and/or by surgical pathology. An interobserver study was performed. RESULTS: The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%, respectively, compared to 92.3% and 68.9%, respectively, for the conventional B-mode images. The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%, respectively, compared to 78.6% and 50.0%, respectively, for the B-mode images. The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes. CONCLUSION: EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity, specificity and accuracy. It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes. (C) 2009 The WJG Press and Baishideng. All rights reserved.
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Giovannini, M., Thomas, B., Erwan, B., Christian, P., Fabrice, C., Benjamin, E., Genevieve, M., Paolo, A., Deprez, P., Robert, Y., Walter, S., Hanz, S., Carl, S., Christoph, D., Pierre, E., Jean-Luc, V. L., Jacques, D., Peter, V., & Andrian, S. (2009). Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: A multicenter study. World Journal of Gastroenterology, 15(13), 1587-1593. https://doi.org/10.3748/wjg.15.1587 (Original work published 2009)