Work and chemical change in isotonic muscular contractions
(1962) Biochimica et Biophysica Acta : international journal of biochemistry and biophysics — Vol. 57, n° 1, p. 1-12 (1962)
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- Authors
Maréchal, Georges 
- Abstract
- Under the conditions where the metabolism of frog sartorius muscle was restricted to a splitting of phosphocreatine, a study has been made of the extent of this splitting as related to activation (maintenance), work, and shortening in 400 msec tetani at 0°C. The maintenance metabolism amounted to 0.45 µmole/g per tetanus, compatible with an assumed heat of hydrolysis and neutralization of 9600 cal/mole, but without availability of a direct myothermal comparison on the same material. Work done by the muscle mobilized extra metabolism, amounting to 9600 cal of work/mole, so that the biochemical basis of the FENN effect has been demonstrated. A correlation of increased metabolism with shortening was not established, although not excluded. It was shown that, because of the dependence of activation metabolism upon length, a direct demonstration of shortening metabolism in free isotonic contractions is not to be expected.
Citations
Mommaerts, W. F. H. M., Seraydarian, K., & Maréchal, G. (1962). Work and chemical change in isotonic muscular contractions. Biochimica et Biophysica Acta : international journal of biochemistry and biophysics, 57(1), 1-12. https://doi.org/10.1016/0006-3002(62)91071-5 (Original work published 1962)