Chemotherapy : friend or foe to cancer vaccines?
(2001) Current Opinion in Molecular Therapeutics — Vol. 3, n° 1, p. 77-84 (2001)
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- Abstract
- Cancer vaccines are oil the threshold of taking their place alongside the more traditional cancer treatment modalities of surgery, radiation therapy and chemotherapy. The toxicology and immunopharmacology of therapeutic cancer vaccines, particularly those that secrete granulocyte macrophage colony stimulating factor (GM-CSF), are currently under active clinical investigation. Interestingly drugs traditionally used for tumor cytoreduction can have both positive and negative effects on host immunity. Exploration of the potential pharmacodynamic interactions of antineoplastic drugs with GM-CSF-secreting vaccines has revealed that low doses of some chemotherapeutics can augment the antitumor immunity induced by GM-CSF-secreting vaccines. These interactions will require through preclinical evaluation to maximize the clinical impact of this type of therapeutic cancer vaccine.
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Citations
Emens, L. A., Machiels, J.-P., Reilly, R. T., & Jaffee, E. M. (2001). Chemotherapy : friend or foe to cancer vaccines? Current Opinion in Molecular Therapeutics, 3(1), 77-84. https://hdl.handle.net/2078.5/138983 (Original work published 2001)