Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release.
(2014) Lab On a Chip : miniaturisation for chemistry, physics, biology and bioengineering — Vol. 14, n° 6, p. 1083 (2014)
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- Authors
- Abstract
- A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi-lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.
- Affiliations
University of Helsinki, Finland Division of Pharmaceutical Chemistry and Technology
Citations
Herranz-Blanco, B., Arriaga, L. R., Mäkilä, E., Correia, A., Shrestha, N., Mirza, S., Weitz, D. A., Salonen, J., Hirvonen, J., & Santos, H. A. (2014). Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release. Lab On a Chip : miniaturisation for chemistry, physics, biology and bioengineering, 14(6), 1083. https://doi.org/10.1039/c3lc51260f (Original work published 2014)