Focal nodular hyperplasia: natural course observed with CT and MRI.
(2000) Journal of Computer Assisted Tomography — Vol. 24, n° 1, p. 61-66 (2000)
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- PURPOSE: The purpose of this work was to assess the natural course of biopsy-proven focal nodular hyperplasia (FNH). METHOD: Eighteen biopsy-proven FNHs in 14 patients (12 women and 2 men) who were followed for at least 6 months with CT and/or MRI were included in the study. The volume of the lesions was calculated twice by two observers using the summation of areas method. Intra- and interobserver variability was assessed by intraclass correlation coefficients. Longitudinal data analysis was performed with generalized estimating equations. RESULTS: The volume of FNH was stable in 6 cases, decreased in 10 cases, and increased in 2 cases. Intra- and interobserver variability in size measurements was 5-10%. Intraclass correlation coefficients were >0.992. Longitudinal data analysis showed that there was a general trend of lesion regression. CONCLUSION: Long-term follow-up and objective measurements performed in patients with biopsy-proven lesions show that the natural course of FNH is variable. In particular, lesion regression is not rare.
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Leconte, I., Van Beers, B., Lacrosse, M., Sempoux, C., Jamart, J., Materne, R., Baudrez, V., & Horsmans, Y. (2000). Focal nodular hyperplasia: natural course observed with CT and MRI. Journal of Computer Assisted Tomography, 24(1), 61-66. https://doi.org/10.1097/00004728-200001000-00013 (Original work published 2000)