Fe(III) and Cu(I) based metal organic gels for in situ drug loading and drug delivery of 5-fluorouracil
(2018) Inorganic Chemistry Communications — Vol. 93, p. 6-9 (2018)
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- Abstract
- We report anticancer drug, 5-fluorouracil (5FU) loaded Iron(III)-fumaric acid (IN·FA@5FU) and Copper(I)-thiourea (CuTu@5FU) metal organic gels (MOGs). These 5FU loaded MOGs are synthesized by in-situ process at ambient conditions. The cumulative release of the loaded anticancer drug 5FU was investigated at pH 5 and physiological pH 7.4. Present studies have shown that the drug release was high at pH 5 compared to pH 7.4. Compared to IN·FA@5FU the drug release of CuTu@5FU is significantly less at pH 5. Due to high 5FU release at acidic pH, the IN·FA@5FU has more advantage than the CuTu@5FU to the treatment of cancer cells. The promising results of in-situ drug loading in the MOGs and drug release provides a good candidates for future drug delivery applications.
- Affiliations
Indian Institute of Technology Mandi India
Citations
Darsi Rambabu, Negi, P., Dhir, A., Gupta, A., & Pooja. (2018). Fe(III) and Cu(I) based metal organic gels for in situ drug loading and drug delivery of 5-fluorouracil. Inorganic Chemistry Communications, 93, 6-9. https://doi.org/10.1016/j.inoche.2018.04.028 (Original work published 2018)